Myeloperoxidase Antigen Background

Myeloperoxidase (MPO) is a heme protein actinic during myeloid adverse that constitutes the above basic of neutrophil azurophilic granules. Produced as a individual alternation precursor, myeloperoxidase is after broken into a ablaze and abundant chain. The complete myeloperoxidase is a tetramer composed of 2 ablaze chains and 2 abundant chains. This agitator produces hypohalous acids axial to the microbicidal action of netrophils.Myeloperoxidase is a lysosomal agitator begin in beef of the myeloid alternation which metabolizes a lot of of the hydrogen achromatize generated by activated phagocytes. It is a above basic of azurophilic cytoplasmic granules that uses hydrogen achromatize to burn a array of ambrosial compounds and chloride ions to hypochlorous acerbic (HOCI), a able oxidant. HOCI is the a lot of bacteriocidal oxidant accepted to be produced by neutrophils. HOCI reacts with proteins to anatomy cytotoxic chloramines. Myeloperoxidase is appear to be a above basic in all myeloid cells, including complete granulocytes and is a above brand to myeloperoxidase mRNA, whose akin decreases with the maturation of the corpuscle and is not apparent from the myelocyte date onwards. Myeloperoxidase is appear to be bidding in neutrophil granulocytes and monocytes in blood, in precursors of granulocytes in the cartilage bottom and in Kupffer beef of the liver.